The Serie A club announced on Saturday that Andrei Shevchenko had been fired after struggling for just over two months in Genoa.
In a statement, Genoa said under-17 coach Abdulaye Konko would remain the caretaker manager until the club receives a permanent replacement for the Ukrainian.
Former AC Milan and Chelsea striker Shevchenko has won just one of his 11 matches in all competitions since being appointed by Genoa on November 7, his team’s latest defeat against Milan in the Italian Cup on Thursday.
Under Shevchenko’s administration, Genoa scored only three times in nine Serie A matches, failed to win six times and lost.
Genoa, which was occupied by American supporters 777 partners in September, is second in Serie A, five points above safety.
Shevchenko guided Ukraine to the Euro 2020 quarter-finals last summer, losing 4-0 to England in Rome.
The 45-year-old scored 175 goals in 324 matches in two spells with Milan, twice emerged as the top scorer in Serie A and won the Serie A title and the 2003 Champions League.