The Russian, looking for a back-to-back Grand Slam crown after winning the US Open last year, beat Rod Laver Arena 6-1, 6-4, 7-6 (7/3) in 1 hour 54 minutes.
“I tried to win the third set, I thought I’d wait (for the tiebreaker), it was successful, so I’m really happy about it,” the world number two told the court.
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“I got off to a good start in Australia last year, won the ATP Cup and reached the final here. I love playing here, I love the hardcourts and I want to do better than last year.”
Medvedev is aiming to do better than his final appearance in last year’s defeat against Novak Djokovic, but with the world number one returning home after his deportation to Serbia, is the nominated favorite for the Russian title.
Medvedev dropped his opening service game against Laksonen, but won again in the next six games to win the first set.
When the 91st-ranked Laconne finally served in the opening game of the second set, the spectators cheered loudly.
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The Swiss were more competitive in the second set, but the second set was still controlling things with its systematic groundstroke.
Laksonen raised his level and topped many long rallies, but Medvedev’s experience made the difference in the third set tiebreaker.